糖心Vlog

Cellular and Molecular Pharmacology Discipline

Bio

Dr. James J. O’Donnell earned a bachelor’s degree in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology (M.I.T.), a master’s degree in Chemistry from the University of Wisconsin-Madison, and a PhD in Pharmacology from Rush University. His PhD work was conducted under the supervision of Dr. Hazel Lum, focusing on the regulation of inflammatory signaling by adherens junction protein p120 catenin in endothelial cells. He continued his training as a T32 postdoctoral fellow in the Department of Medicine at University of Chicago and subsequently served as a postdoctoral fellow at the Indiana University School of Medicine-South Bend. Dr. O’Donnell joined RFUMS as an Assistant Professor in 2016 and was appointed Chair of the Discipline of Cellular and Molecular Pharmacology in 2026.

In addition to overseeing the pharmacology curriculum, Dr. O’Donnell teaches a wide variety of subjects within pharmacology at Chicago Medical School (CMS). He is currently co-course director of the Cardiovascular-Pulmonary-Renal (CPR) course in CMS. He also directs graduate courses such as Pharmacology Core, Advanced Molecular Pharmacology, and Seminars in Cellular and Molecular Pharmacology. In the past, he served as co-course director of the Medical Pharmacology course at CMS. He also was founding course director of Fundamentals of Pharmacology; Pharmacology I, II, and III; and Forensic Toxicology in the College of Pharmacy.

Dr. O’Donnell’s current scholarly interests include pharmacokinetics and toxicology, the latter with a particular focus on drug impairment and forensics. He is co-editor of the 4th and lead editor of the 5th edition of O’Donnell’s Drug Injury, and chief editor of Drug Discovery and Development, 3rd Edition.

Dr. O’Donnell served as President of the American Society for Pharmacology and Experimental Therapeutics-Great Lakes Chapter from 2023 to 2025. He is a member of the American Academy of Clinical Toxicology (AACT), the American College of Clinical Pharmacology (ACCP), and the American Society for Pharmacology and Experimental Therapeutics (ASPET).

Publications

Peer-reviewed publications

• Mosnaim AD, Wolf ME, III O'Donnell JJ, Hudzik T. β-Phenylethylamine and various monomethylated and para-halogenated analogs. Acute toxicity studies in mice. Drug Chem Toxicol. 2020 Jul;43(4):369-372. doi: 10.1080/01480545.2018.1551899. Epub 2019 Jan 7. PMID: 30614291.
• O'Donnell JT, O'Donnell JJ, Vogenberg FR. Forensic Analysis in Drug Litigation Finds Most Errors Occur with Commonly Used Therapies and Practices. P T. 2019 Mar;44(3):118-121. PMID: 30828231; PMCID: PMC6385734.
• Tian Y, Gawlak G, O'Donnell III JJ, Birukova AA, Birukov KG. Activation of Vascular Endothelial Growth Factor (VEGF) Receptor 2 Mediates Endothelial Permeability Caused by Cyclic Stretch. J Biol Chem. 2016 May 6;291(19):10032-45. doi: 10.1074/jbc.M115.690487. Epub 2016 Feb 16. PMID: 26884340; PMCID: PMC4858957.
• Gawlak G, Son S, Tian Y, O'Donnell III JJ, Birukov KG, Birukova AA. Chronic high-magnitude cyclic stretch stimulates EC inflammatory response via VEGF receptor 2-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1062-70. doi: 10.1152/ajplung.00317.2015. Epub 2016 Mar 18. PMID: 26993523; PMCID: PMC4935472.
• Tian Y, Gawlak G, O'Donnell III JJ, Mambetsariev I, Birukova AA. Modulation of Endothelial Inflammation by Low and High Magnitude Cyclic Stretch. PLoS One. 2016 Apr 29;11(4):e0153387. doi: 10.1371/journal.pone.0153387. PMID: 27128976; PMCID: PMC4851399.
• Tian Y, Tian X, Gawlak G, O'Donnell III JJ, Sacks DB, Birukova AA. IQGAP1 regulates endothelial barrier function via EB1-cortactin cross talk. Mol Cell Biol. 2014 Sep 15;34(18):3546-58. doi: 10.1128/MCB.00248-14. Epub 2014 Jul 14. PMID: 25022754; PMCID: PMC4135611.
• Gawlak G, Tian Y, O'Donnell III JJ, Tian X, Birukova AA, Birukov KG. Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex. FASEB J. 2014 Jul;28(7):3249-60. doi: 10.1096/fj.13-245142. Epub 2014 Apr 4. PMID: 24706358; PMCID: PMC4062829.
• Cowan C, Muraleedharan CK, O'Donnell III JJ, Singh PK, Lum H, Kumar A, Xu S. MicroRNA-146 inhibits thrombin-induced NF-κB activation and subsequent inflammatory responses in human retinal endothelial cells. Invest Ophthalmol Vis Sci. 2014 Jul 1;55(8):4944-51. doi: 10.1167/iovs.13-13631. PMID: 24985472.
• O'Donnell III JJ, Birukova AA, Beyer EC, Birukov KG. Gap junction protein connexin43 exacerbates lung vascular permeability. PLoS One. 2014 Jun 26;9(6):e100931. doi: 10.1371/journal.pone.0100931. PMID: 24967639; PMCID: PMC4072707.
• O'Donnell JT, Marks DH, Danese P, O'Donnell III JJ. Drug-induced liver disease: primer for the primary care physician. Dis Mon. 2014 Feb;60(2):55-104. doi: 10.1016/j.disamonth.2013.11.002. PMID: 24507900.
• O'Donnell III JJ, O'Donnell JT, Juettner VM. Clinical pharmacology for the primary care physician. Dis Mon. 2012 Oct;58(10):558-610. doi: 10.1016/j.disamonth.2012.07.003. PMID: 22999026.
• O'Donnell III JJ, Zhuge Y, Holian O, Cheng F, Thomas LL, Forsyth CB, Lum H. Loss of p120 catenin upregulates transcription of pro-inflammatory adhesion molecules in human endothelial cells. Microvasc Res. 2011 Sep;82(2):105-12. doi: 10.1016/j.mvr.2011.04.008. Epub 2011 Apr 30. PMID: 21554891; PMCID: PMC3149739.
• Zhang J, O'Donnell III JJ, Holian O, Vincent PA, Kim KS, Lum H. P120 catenin represses transcriptional activity through Kaiso in endothelial cells. Microvasc Res. 2010 Sep;80(2):233-9. doi: 10.1016/j.mvr.2010.04.001. Epub 2010 Apr 9. PMID: 20382170; PMCID: PMC2917640.
• Jensen, T.R.; O’Donnell III, J. J.; Marks, T.J. 2004.  Do/fn-Mediated Ring-Opening Ziegler Polymerization (ROZP) and Copolymerization with Mono- and Disubstituted Methylenecyclopropanes.  Diverse Mechanisms and a New Chain-Capping Termination Process.   Organometallics. 23(4), 740-754.
• Seyam, A.M.; Stubbert, B.D.; Jensen, T.R.; O’Donnell III, J.J.; Stern, C.L.; Marks, T.J. 2004. Organolanthanide Constrained Geometry Complexes Modified for Catalysis: Synthesis, Structure, and Aminoalkane Hydroamination Properties of a Pyrrolidine-substituted Constrained Geometry Organolutetium Complex. Inorganica Chimica Acta, 357, 4029-4035.
• C.L.; Marks, T.J. 2004. Organolanthanide Constrained Geometry Complexes Modified for Catalysis: Synthesis, Structure, and Aminoalkane Hydroamination Properties of a Pyrrolidine-substituted Constrained Geometry Organolutetium Complex. Inorganica Chimica Acta, 357, 4029-4035.

Books

• O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Taylor & Francis Publishing; 2026.
• O’Donnell III JJ, Somberg J, Idemyor V., O’Donnell JT, Eds. Drug Discovery and Development. Taylor & Francis Publishing. 2020.
• O’Donnell, J.T., O’Donnell III, J.J. eds. O’Donnell’s Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.

Book Chapters

• O’Donnell III JJ, O’Donnell JT. “Forensic Drug Testing” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• O’Donnell JT, O’Donnell III JJ, Vaughn W. “Involuntary Intoxication” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• Tedford SE, O’Donnell JT, O’Donnell III JJ. “Marijuana: Pharmacology, Toxicology, and Forensic Issues” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• O’Donnell JT, O’Donnell III JJ. “Alcohol” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• O’Donnell JT, O’Donnell III JJ. “Pharmacist Malpractice and Liability” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• O’Donnell JT, O’Donnell III JJ., Tedford SE. “Anticoagulants: Therapeutics, Risks, and Toxicities” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• O’Donnell JT, O’Donnell III JJ. “Medication Errors” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• Parran D, O’Donnell JT, O’Donnell III JJ. “Fetal Drug Exposure” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• Splawski JA, O’Donnell JT, O’Donnell III JJ. “Dangers of Opioids” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• O’Donnell JT, O’Donnell III JJ., Marks DH, Danese P. “Drug Induced Liver Disease” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• O’Donnell III JJ., O’Donnell JT “Drug Induced Falls”. In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• O’Donnell JT, O’Donnell III JJ. “Allergic Drug Reactions” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• O’Donnell III JJ., O’Donnell JT, Juettner V. “General Principles of Pharmacology” In: O’Donnell III JJ, O’Donnell JT, Patel GP, Splawski JA, eds. O’Donnell’s Drug Injury, 5th Ed. Tucson, AZ: Taylor & Francis Publishing; 2026.
• O’Donnell III JJ, Call GB, “Calcium Regulating Hormones and Other Agents Affecting Bone”, In: Osborn SI and Wecker L, eds. Brody’s Human Pharmacology, 7th ed. Elsevier, Inc. 2024.
• O’Donnell III JJ, Call GB, “Drug Therapy for the Management of Thyroid Disorders”, In: Osborn SI and Wecker L, eds. Brody’s Human Pharmacology, 7th ed. Elsevier, Inc. 2024.
• Call GB, O’Donnell III JJ, “Treatment of Hypothalamic and Pituitary Disorders”, In: Osborn SI and Wecker L, eds. Brody’s Human Pharmacology, 7th ed. Elsevier, Inc. 2024.
• O’Donnell III JJ, Call GB, “The Pharmacology of Adrenocorticosteroid Disorders”, In: Osborn SI and Wecker L, eds. Brody’s Human Pharmacology, 7th ed. Elsevier, Inc. 2024.
• O’Donnell III JJ. “Introduction to Endocrine Pharmacology”. In: Osborn S and Wecker L, eds. Brody’s Human Pharmacology, 7th ed. Elsevier, Inc. 2024.
• O’Donnell III JJ, Somberg J, O’Donnell JT, “Introduction to Drug Discovery and Development”. In: O’Donnell III JJ, Somberg J, Idemyor V., O’Donnell JT, eds. Drug Discovery and Development. Taylor & Francis Publishing. 2020.
• O’Donnell JJ, O’Donnell JT. Drug Induced Falls. In Bakken GM, Larue C, Cohen HH, Eds. Slips, Trips, Missteps and Their Consequences. Third Edition. L&J Publ. Tuscon, 2020.
• O’Donnell J.T., O’Donnell III, J.J. Pharmacology of Marijuana. In: Nesci J., St. Louis J.P. and Tiftickjian J.M. Medicolegal Aspects of Marijuana Arizona Edition. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2018.
• O’Donnell J.T., O’Donnell III, J.J. Marijuana: Pharmacology and Medical-Legal Issues. In: Callahan L.M. and Tiftickjian J.M. Medicolegal Aspects of Marijuana Washington Edition. Tuscon, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.
• O’Donnell III, J.J., O’Donnell J.T., and ImObersteg, A.D. Forensic Drug Testing. In: O’Donnell J.T., O’Donnell III, J.J., eds. O’Donnell’s Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.
• O’Donnell III, J.J., O’Donnell, J.T., Juettner V. General Principles of Pharmacology. In: O’Donnell J.T., O’Donnell III, J.J., eds. O’Donnell’s Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.
• O’Donnell, J.T., O’Donnell III, J.J. Allergic Drug Reactions. In: O’Donnell J.T., O’Donnell III, J.J. eds. O’Donnell’s Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.
• O’Donnell, J.T., Marks, D.H., Danese, P., and O’Donnell III, J.J. Drug-induced Liver Disease. In: O’Donnell J.T., O’Donnell III, J.J. eds. O’Donnell’s Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.
• O’Donnell, J.T., O’Donnell III, J.J. Dangers of Opiates. In: O’Donnell J.T., O’Donnell III, J.J. eds. O’Donnell’s Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.
• O’Donnell III, J.J., O’Donnell, J.T. Drug-induced Falls. In: O’Donnell J.T., O’Donnell III, J.J., eds. O’Donnell’s Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.
• O’Donnell III, J.J., O’Donnell, J.T., ImObergsteg, A.D. Drug Testing in the Workplace. In: O’Donnell J.T., O’Donnell III, J.J., eds. O’Donnell’s Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.
• O’Donnell, J.T., O’Donnell III, J.J. Alcohol. In: O’Donnell J.T., O’Donnell III, J.J., eds. O’Donnell’s Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.
• O’Donnell, J.T., O’Donnell III, J.J., Benjamin, D.M. Marijuana: Pharmacology and Medical-Legal Issues. In: O’Donnell J.T., O’Donnell III, J.J., eds. O’Donnell’s Drug Injury. 4th ed. Tucson, AZ: Lawyers & Judges Publishing Company, Inc.: 2016.
• Benjamin D, O’Donnell JT and O’Donnell JJ. Pharmacology and Toxicology of Marijuana. In: Legal Medicine and Medical Ethics, 9th Edition, American College of Legal Medicine, 2015.
• O’Donnell JT and O’Donnell JJ. Pharmacology of Marijuana, in Tiftickjian J. Medical Legal Aspects of Marijuana – Colorado Edition. L&J Publishers, Tucson, 2015.
• O’Donnell JT and O’Donnell JJ. Alcohol in Civil Litigation. In: Caplan Y and Goldberger B eds., Garriott’s Medicolegal Aspects of Alcohol, 6th Edition, October 2014.
• O’Donnell III J.J., O’Donnell JT, and Juettner VM. 2012. In: Basic Pharmacology in Drug Injury: Liability, Analysis, and Prevention, 3rd Ed. L&J Publ, Tucson, AZ.